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Sains Malaysiana 54(1)(2025):
131-150
http://doi.org/10.17576/jsm-2025-5401-11
Angiogenesis Effects of Dental Stem Cells
Cultured on Polymer Scaffolds
(Kesan Angiogenesis Sel Stem Pergigian yang
Dibiakkan pada Perancah Polimer)
NUR NAJMI MA1¶,
NOOR HASILA AD1&, FAZREN AZMI3&,
THANAPHUM OSATHANON4&, ROHAYA
MEGAT ABDUL WAHAB2& & FARINAWATI YAZID2,*¶
1Programme of Biomedical Science, Centre of
Toxicology & Health Risk Studies, Faculty of Health Sciences, Universiti
Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
Received: 20
February 2024/Accepted: 6 November 2024
¶These authors contributes equally to this
work
&These authors contribute equally to this
work
Abstract
Following the PRISMA-ScR guidelines, three electronic
databases were searched (PubMed, Scopus and Web of Science) to
identify the related studies using specific keywords and terms. The abstracts
were evaluated for inclusion and exclusion criteria. The included publications
were descriptively analysed. Out of 296 articles found, only
nine were included for analysis. The objective of this study was to assess the
angiogenesis effects of dental stem cells cultured in a polymer scaffold by
evaluating their ability to promote blood vessel formation, cell viability, and
tissue regeneration, thereby providing insights into their potential
therapeutic applications in regenerative medicine. Previous
studies mainly focused on polymer scaffold research, neglecting the crucial
aspect of angiogenesis in pulp regeneration. Despite DPSCs' versatility in bone
regeneration, more research is needed to understand their relationship with
angiogenesis. The untapped potential of DPSCs in promoting blood vessel
formation and tissue regeneration requires further exploration. Limited
investigation exists on how the combination of stem cell, angiogenic, and
dentin markers affects angiogenesis in DPSCs. The morphological changes DPSCs
undergo in scaffold environments and the gene/protein expression analyses in
DPSCs on scaffolds with angiogenic factors are areas that still need
exploration. This research gap holds promise for enhanced understanding and advancement in tissue engineering and regenerative medicine,
particularly in DPSCs' connection with scaffolds and angiogenesis. There
has been limited research on the interplay of DPSCs, polymer scaffolds, and
angiogenesis, with unexplored combined consequences on tissue regeneration.
Scaffold-based techniques to investigate angiogenesis with DPSCs are uncommon.
Further research might transform tissue engineering and regenerative medicine,
spanning beyond dentistry.
Keywords:
Angiogenesis; dental pulp stem cells; dentinogenesis; scaffold
Abstrak
Mengikut
garis panduan PRISMA-ScR, tiga pangkalan data elektronik (PubMed, Scopus dan
Web of Science) telah dicari untuk mengenal pasti kajian berkaitan menggunakan
kata kunci dan istilah tertentu. Abstrak dinilai untuk kriteria kemasukan dan
pengecualian. Penerbitan yang terpilih telah dianalisis secara deskriptif.
Daripada 296 artikel yang diperoleh, hanya sembilan diterima untuk analisis.
Objektif kajian ini adalah untuk menilai kesan angiogenesis sel stem pergigian
yang dikultur dalam perancah polimer dengan menilai keupayaan mereka untuk
menggalakkan pembentukan saluran darah, daya tahan sel dan penjanaan semula
tisu, seterusnya memberikan pandangan tentang potensi aplikasi terapeutik
mereka dalam perubatan regeneratif. Kajian terdahulu tertumpu terutamanya pada
penyelidikan perancah polimer, mengabaikan aspek penting angiogenesis dalam
penjanaan semula pulpa. Walaupun DPSC serba boleh dalam penjanaan semula
tulang, lebih banyak penyelidikan diperlukan untuk memahami hubungan mereka
dengan angiogenesis. Potensi DPSC yang belum diterokai dalam menggalakkan
pembentukan saluran darah dan penjanaan semula tisu memerlukan penerokaan
lanjut. Penyelidikan terhad wujud tentang bagaimana gabungan penanda sel stem,
angiogenik dan dentin mempengaruhi angiogenesis dalam DPSC. Perubahan morfologi
yang dialami DPSC dalam persekitaran perancah dan analisis ekspresi gen/protein
dalam DPSC pada perancah dengan faktor angiogenik masih memerlukan penerokaan.
Jurang penyelidikan ini menjanjikan pemahaman dan kemajuan yang lebih baik
dalam kejuruteraan tisu dan perubatan regeneratif, terutamanya dalam hubungan
DPSC dengan perancah dan angiogenesis. Penyelidikan yang terhad mengenai
interaksi DPSC, perancah polimer dan angiogenesis serta tiada penerokaan
mengenai penggabungan semua faktor ini dalam penjanaan semula tisu. Teknik
berasaskan perancah untuk mengkaji angiogenesis dengan DPSC jarang berlaku.
Justeru, penyelidikan lanjut mungkin mengubah kejuruteraan tisu dan perubatan
regeneratif pergigian.
Kata kunci:
Angiogenesis; dentinogenesis; perancah; sel stem pulpa pergigian
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